This review summarizes the diagnostic work-up of children with a first acquired demyelinating syndrome, differential diagnosis, the role of MRI, cerebrospinal fluid (CSF) markers, antibody testing, serum neurofilament light chain, optical pathway assessment and the 2024 McDonald criteria.
M. Margoni, Massimo Filippi, M. Rocca· Expert Review of Neurotherap...· 0 citations
BACKGROUND
Multiple sclerosis (MS) is a chronic, immune-mediated disorder of the central nervous system (CNS). In Egypt, its occurrence is approximately 13.7 per 100,000 inhabitants. The average age of onset for relapsing-remitting MS (RRMS) is between the second and fourth decades of life.
OBJECTIVES
To determine th...
A. Fouad, Abdallah Saad, Hadeer Mohamed Abd El-Aziz et al.· Multiple Sclerosis and Relat...· 0 citations
The clinical patterns of acute attacks and relapses of multiple sclerosis, NMOSD and MOGAD are discussed, including the clinical and para-clinical modalities that are critical for timely recognition and diagnosis, and available evidence regarding treatment selection and responsiveness is presented.
Yu-Jing Li, Wei Jiang, Chao Zhang et al.· Cell Death and Differentiati...· 0 citations
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disorder of the central nervous system for which more than 20 disease-modifying therapies (DMTs) are currently available. Recent advances in diagnostic criteria, biomarker development, and understanding of disease biology have challenged traditiona...
Moein Amin, Kaitlyn N. Palmer, A. Samara et al.· Drugs· 0 citations
Multiple Sclerosis (MS) is a chronic immune-mediated neurodegenerative disorder of the Central Nervous System (CNS) that affects more than 2.8 million people worldwide. It is recognized as one of the leading causes of non-traumatic neurological disability among young adults. It is an inflammatory demyelination disease...
K. Ravi, K. Arora· Current Neurovascular Resear...· 0 citations
Key updates include expansion of dissemination in space to incorporate the optic nerve, integration of relapsing and progressive onset MS within a unified diagnostic framework, provision for diagnosis in selected asymptomatic individuals, dispensing with the requirement for dissemination of time in certain situations a...
P. Siriratnam, Mineesh Datta, Katherine A. Buzzard et al.· Autoimmunity Reviews· 0 citations
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