TL;DR
The present investigation successfully pinpointed five critical genes alongside one key cellular population, collectively providing potential molecular insights and candidate targets for further investigation into AS calcification.
Osteoporosis is a highly prevalent age-related disorder, and accumulating evidence suggests that it does not arise in isolation but is intrinsically linked to the aging process. Here, we employed integrative methods to systematically identify the relationship between aging and osteoporosis, and uncover the critical cel...
Objective To identify metabolism-related genes associated with osteoporosis and evaluate their diagnostic potential through integrative transcriptomic analysis and clinical validation. Methods Single-cell RNA sequencing data from GSE169396 were analyzed using the Seurat package to investigate interactions between monoc...
These novel anoikis‑related molecular signatures associated with VC are involved in cell adhesion, VSMC homeostasis, chaperone‑mediated cytoprotection, and matrix remodeling.
Investigation of MS-related prognostic genes and their potential biological relevance in CRC progression finds potential clues for future studies of CRC prognosis and MS-related tumor biology.
The important role of macrophage-associated nucleotide metabolism in HTS is revealed and NCF1 and GPR34 are identified as potential biomarkers and therapeutic targets.
The aim of the present study was to elucidate the cellular and molecular mechanisms underlying refractory recurrent in-stent restenosis (RISR), thereby facilitating the identification of potential therapeutic targets. Coronary blood samples were obtained from culprit lesions of patients with RISR and non-ISR controls a...
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