Coumarin derivatives exhibit significant biological and pharmacological
activities, motivating the design of new coumarin-based compounds. This study aimed to synthesize novel coumarin-3-carboxamides using a simple and efficient multicomponent reaction, and to
investigate their structural and electronic properties...
Behnam Gharehbaghi, N. Shajari, H. Yahyaei· Current Organic Synthesis· 0 citations
The results indicate that structural modification of sulfadiazine through heterocyclic ring formation significantly enhances antibacterial activity and binding affinity, suggesting their potential as promising antimicrobial agents.
Rusul Zamil Abdulhassan, N. Majeed· Applied Chemistry for Engine...· 0 citations
Herein, we report the synthesis of new 1,4-benzothiazine-1,1-dioxide derivatives bearing bis(1,2,3-triazole) moieties via click chemistry in good to high yields and fully characterized by 1H NMR, 13C NMR and HRMS. The compounds were evaluated using a combined in silico approach, including physicochemical, pharmacokinet...
Ezaddine Irrou, Chagaleti Bharath Kumar, Y. Riadi et al.· Computational biology and ch...· 0 citations
The synthesis and evaluation of novel bis-triazole derivatives, designed to evaluate their antimicrobial activity against clinically relevant pathogens and to establish structure-activity relationships for future optimization, provide a basis for further optimization of triazole-based antimicrobial agents.
Ahmed M. Abobakr, Rasha A. Nabil, H. H. Temirek et al.· Polycyclic aromatic compound...· 0 citations
A series of substituted β-lactam derivatives (3a–e) were synthesized via Schiff base intermediates using a Staudinger [2+2] cycloaddition reaction and characterized by FT-IR and 1H NMR spectroscopy. DFT calculations (B3LYP/6-31G(d)) were performed to investigate molecular geometry, electronic properties, and reactivity...
Umme Aiman Liza, Sumaiya Khan, M. Aman et al.· European Journal of Chemistr...· 0 citations
A sustainable and environmentally friendly approach for the synthesis of novel pyrimidine Schiff base derivatives through a multicomponent grinding reaction conducted at room temperature under solvent-free conditions is reported, suggesting that compound (3) may serve as a promising lead candidate for breast cancer the...
Alaa M. Abu Alnjaa· Oriental Journal of Chemistr...· 0 citations
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