A Bayesian latent block model that jointly partitions assessors and items under a Plackett--Luce observation model reveals tissue-driven sample structure while compressing gene-level heterogeneity into interpretable blocks and Rank-based GSEA of posterior gene scores supports biological interpretation.
Abstract
We introduce a Bayesian latent block model that jointly partitions assessors and items under a Plackett--Luce observation model. Assessors are assigned to $C$ clusters and items to $K$ blocks; items in a block share a common strength parameter within each assessor cluster, yielding a parsimonious $C\times K$ co-clustering representation. Independent Gnedin priors infer $C$ and $K$. Data augmentation gives conjugate Gibbs updates and a tractable MCMC sampler with split-merge moves. Simulations characterize recovery and posterior uncertainty as signal, ranking depth, and group balance vary. Applied to the cancer gene atlas (TCGA) pan-cancer top-500 gene-expression rankings, the model reveals tissue-driven sample structure while compressing gene-level heterogeneity into interpretable blocks. Rank-based GSEA of posterior gene scores supports biological interpretation.
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