It is demonstrated that CFA attenuates Pb-induced behavioral and biochemical alterations and suggest that its neuroprotective effects are mediated, at least in part, through TFEB-associated pathways.
BACKGROUND
Neuroinflammation and oxidative stress play vital roles in the pathogenesis of neurodegenerative diseases characterized by cognitive decline. Ursolic acid (UA), a natural pentacyclic triterpenoid compound with reported anti-inflammatory and antioxidant properties, has been suggested as a potential neuroprote...
Ga-Young Choi, Seohyeong Lee, A. Je et al.· Phytomedicine· 0 citations
AIM
Ketamine (KTM) is widely used in clinical settings for its anesthetic, analgesic, and antidepressant properties. However, prolonged or repeated KTM exposure can induce neurotoxicity through oxidative stress, neuroinflammation, and apoptotic mechanisms. This study investigated the neuroprotective effects of Chrysin...
Onur Karaca, Özge Kandemir, Hasan Şimşek et al.· Neurotoxicology and Teratolo...· 0 citations
EA attenuates scopolamine-induced memory deficits, accompanied by improvements in oxidative stress markers, neuroinflammatory gene expression, and cholinergic parameters, which suggest a potential neuroprotective role of EA.
Arezoo Rajabian, Amir Hossein Assaran, Farshad Mirzavi et al.· Research in Pharmaceutical S...· 0 citations
MyR attenuated RTN-induced neurotoxicity and was associated with improved behavioral performance, reduced OS, and preservation of neuronal morphology, which support the protective potential of MYR against RTN-induced neurotoxicity exhibiting Parkinsonian-like features.
O. Ozhan, Zehranur Erikci, A. Yıldız et al.· Journal of Molecular Histolo...· 0 citations
Background Depression imposes a heavy global disease burden accompanied by mitochondrial injury and neuroinflammation predominantly in the prefrontal cortex. Using a chronic unpredictable mild stress (CUMS) rat model, this study aimed to explore the impacts of scopolamine on brain mitochondrial function and its underly...
Yun-Xiao Zhang, Hao-Hon Fu, Wan-Pu Yan et al.· Journal of Inflammation Rese...· 0 citations
Abstract Objectives Diabetes mellitus (DM) is characterised by extended inflammation and oxidative stress, leading to hippocampal neuronal apoptosis and memory dysfunction. Antioxidant and neuroprotective effects have been identified in chlorogenic acid (CGA). However, its function in hippocampal pathology under diabet...
D. C. R. Sari, Junaedy Yunus, Ari Susilowati et al.· Journal of Complementary and...· 0 citations
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