Quercetin exerts radioprotective effects against radiation-induced intestinal injury with involvement of the PI3K-AKT/Caspase-3 axis

Dihydroquercetin Activates AMPK/SIRT1/PGC-1α Signaling to Attenuate Arsenic Trioxide-Induced Apoptosis and Ferroptosis in AC16 Cells and HUVECs

Arsenic trioxide (ATO) is a first-line therapeutic agent for acute promyelocytic leukemia (APL), but its clinical utility is constrained by dose-dependent cardiotoxicity. This study aimed to systematically evaluate the cytoprotective potential of dihydroquercetin (DHQ), a natural flavonoid derived from coniferous speci...

Estragole Induces Apoptosis in A549 Lung Cancer Cells via ROS-mediated Oxidative Stress and Modulation of Caspase Activation and Bax/Bcl-2 Pathway

Lung cancer remains a major cause of death globally, responsible for a significant portion of all cancer-related deaths despite advancements in therapeutic modalities. Consequently, there is a great demand for new treatment strategies that can improve anti-cancer efficiency while minimizing toxicity in vivo ....

Protective effects of boron on radiation-induced intestinal injury and associated microRNA changes.

PURPOSE Radiation-induced intestinal injury (RIII) remains a significant dose-limiting toxicity despite advances in radiotherapy techniques. Boron has been suggested to exert beneficial effects on intestinal structure and oxidative stress; however, its potential radioprotective effects have not been fully characterized...

Saikosaponin A Induces Apoptosis in HCT116 Colorectal Cancer Cells via ROS-Mediated ER Stress and p38/JNK MAPK Pathway Activation: in Vitro and in Vivo Evidence

Colorectal cancer (CRC) is the third most prevalent cancer globally, with limited effective treatment options and significant chemotherapy resistance. Saikosaponin A (SSA), a triterpenoid saponin from Radix Bupleuri, exhibits anti-inflammatory and antitumor properties, but its mechanism of action in CRC remains und...

Propolis ameliorates cisplatin-induced nephrotoxicity via activation of Nrf2/HO-1 signaling pathway in rats

Quercetin Suppresses Migration and Promotes Mitochondrial Apoptosis Through KRAS-Associated Signaling in Caco-2 Colorectal Cancer Cells

Colorectal cancer (CRC) remains a leading cause of cancer related mortality owing to uncontrolled proliferation, metastatic progression, and resistance to apoptosis. Quercetin, a naturally occurring dietary flavonoid, has attracted considerable interest as a potential anti-cancer agent. This study evaluated the anti-ca...