TL;DR
Together, these findings revealed how mice flexibly deploy distinct exploratory strategies during adaptive behavior, highlighting OFC’s role in supporting reward and error-guided learning through distinct corticocortical interactions.
Flexible behavior depends on neural mechanisms that integrate memory with ongoing motivational demands. Studies have revealed dopamine (DA) to have an essential role in mediating memory, behavioral flexibility, and decision-making, yet the dopaminergic contributions within prefrontal-hippocampal circuits remain poorly...
It is indicated that LC inputs to the hippocampus preferentially facilitate spatial memory updating rather than uniformly enhancing spatial learning, and a complementary framework for quantifying the organization of radial-maze trajectories is introduced.
Reward-predictive cues can influence decision-making and promote the pursuit of specific outcomes. This influence is classically studied using specific Pavlovian-to-instrumental transfer (sPIT), in which Pavlovian cues bias action selection and promote the instrumental action (often a left or right lever press) directe...
These findings identify the LP-ACC as a thalamocortical pathway that implements a contrastive, history-referenced representation of sensory evidence during decisions, and identifies LP-ACC as a thalamocortical pathway that implements a contrastive, history-referenced representation of sensory evidence during decisions.
Researchers find that brief high-frequency bursts of neural firing in mouse thalamus and cortex track the value of sensory cues during learning and invert their stimulus selectivity in response to task rule inversions, and show suppressing these bursts impairs learning.
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