Sep 2026· Journal of Macromolecular Science, Part B· Vol 65, pp. 1369 - 1395· 6 citations· 86 references
TL;DR
Haluronic acid-functionalized polyethylene glycol-polycaprolactone (HA-PEG-PCL) copolymers are emerging as a highly effective nanocarrier platform for targeted cancer therapy that integrates tumor-specific targeting, controlled drug release and enhanced pharmacokinetics to address the limitations of conventional chemotherapy.
Melanoma remains one of the most aggressive forms of skin cancer, characterized by high metastatic potential and risks of tissue trauma and post-surgical recurrence, with limited therapeutic options currently available. While conventional monotherapies often fail to provide comprehensive and efficient treatment, nanopa...
D. V. Miranda, A. A. P. Mansur, H. Mansur et al.· Gels· 0 citations
This review examines studies published from 2019 to 2026, and connects the structural parameters of HA with quantitative drug delivery efficiency and therapeutic performance, and summarizes the current design principles of HA-based nanocarriers while critically discussing the remaining challenges.
Hao Wu, P. Snetkov, Jing-Ran Zhang et al.· Nanotechnology· 0 citations
The potential of PEG-HA-EGCG micelles as a polysaccharide-based nanoplatform integrating high-capacity drug loading, tumor-responsive release, and targeted intracellular delivery for cancer therapy is demonstrated.
D. Nguyen, Hoang Duy Nguyen, Anh Quan Hoang et al.· International Journal of Bio...· 0 citations
In conclusion, while nanocarriers offer significant advancements in targeted cancer therapy, their successful clinical implementation depends on overcoming various scientific, technical, and regulatory challenges.
Busayo Olamide Tomoh· International Journal of Med...· 0 citations
Breast cancer remains a major global health concern, highlighting the need for advanced drug delivery strategies that can improve therapeutic efficacy while minimizing systemic toxicity. Although several reviews have discussed polymeric nanocarriers for breast cancer therapy, many have primarily focused on specific p...
Nazanin Amiryaghoubi, B. Kim· ACS Applied Nano Materials· 0 citations
In vitro and in vivo studies further demonstrated the potential of this nanoparticle system for controlled, targeted, and biocompatible delivery of anticancer agents.
Madhusudan Maity, Niranjan Panda, Subas C. Dinda et al.· Recent Patents on Nanotechno...· 0 citations
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