We provide an update on the current psychiatric research for DBS and TMS and what the field has learned about causal circuitry implicated in anxiety and anxiety-related disorders. Recent refinement of DBS and TMS techniques have both improved their safety and efficacy as anxiety treatments and elucidated the pathological circuitry and areas causally involved in psychiatric disease. Anxiety is a debilitating hallmark of many psychiatric disorders. A significant portion of patients do not achieve sufficient benefit from psychotherapy and medication, so other therapies are being investigated. Neuromodulation, which involves targeted stimulation of neural circuitry, is FDA cleared for obsessive compulsive disorder (OCD) and depression and is an option for some patients whose anxiety have not responded to standard therapy. Over the past several years, neuromodulation protocol and technology advancements have continued to evolve the psychiatric treatment paradigm. Transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS) are two of the most extensively studied neuromodulation techniques in psychiatry.
This review surveys the current literature to clarify the mechanisms of action of neurostimulation across multiple levels of biological integration, ranging from large-scale neural circuits to cellular and subcellular processes and engages in a critical epistemological reflection.
F. Bambico, A. Nicoglou, J. Relente et al.· Molecular Psychiatry· 0 citations
Psychiatric disorders, led by major depressive disorder, bipolar affective disorder, treatment-resistant depression (TRD), and severe anxiety spectrum conditions, constitute a foremost contributor to global disease burden and societal disability. While monoaminergic psychopharmacology and evidence-based psychotherapies...
Radosław Swędrak, Zuzanna Dobrakowska, Jakub Klepacz· International Journal of Inn...· 0 citations
Abstract Background Non-invasive brain stimulation (NIBS) has emerged as a valuable therapeutic approach in psychiatry, offering an alternative to conventional pharmacological treatments. Evidence indicates that NIBS can be highly effective in certain conditions; for instance, repetitive transcranial magnetic stimulati...
G. Kranz· International Journal of Neu...· 0 citations
: Common mental disorders that decrease the quality of life include Attention-Deficit/Hyperactivity Disorder (ADHD) and Major Depressive Disorder (MDD). A lot of patients are not receptive to medication or psychotherapy. This generates the necessity of alternative therapies. The question this paper poses is how neurote...
Yi-Cheng Zeng· Proceedings of the 4th Inter...· 0 citations
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