TL;DR
Investigating the relationship between DHRS2 and EMT-related genes in breast cancer suggests that DHRS2 regulates EMT through the Wnt/β-catenin signalling pathway, and limited changes observed in certain EMT markers indicate that DHRS2 may promote cell migration through partial EMT rather than complete EMT.
Elevated MXRA5 expression exhibited a positive correlation with advanced lymph node metastasis and impaired clinical prognosis, and its potential as a valuable prognostic biomarker and therapeutic target for managing metastatic disease is revealed.
Colorectal cancer (CRC) remains a major cause of cancer death worldwide, largely due to metastasis and drug resistance. The epithelial–mesenchymal transition (EMT) is known to drive CRC metastasis. ATM kinase has been reported to influence the Akt signaling pathway, which itself plays a central role in EMT....
Background: Triple-negative breast cancer (TNBC) is exceptionally aggressive, with a high recurrence rate, resistance to chemotherapy, and a tendency to metastasize. The long non-coding RNA growth arrest-specific 5 (GAS5) is associated with TNBC progression; however, the specific mechanism still requires further explor...
Breast cancer stem cells (BCSCs) drive tumor progression, metastasis, and therapeutic resistance. Sirtuin 1 (SIRT1) has been implicated in stem cell regulation, but its context-dependent role in BCSC maintenance and the underlying molecular mechanisms remain poorly defined. SIRT1 expression was evaluated in human breas...
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