An association of STK35L1 and EGFR in BC is reported, highlighting STK35L1 as a potential prognostic biomarker and therapeutic target and suggesting that EGFR-STAT3 signaling may regulate STK35L1 and EGFR expression.
The CD24-EDN1-NFκB axis has a crucial role in PTX resistance in TNBC, according to this study, offering a new therapeutic target for treating chemotherapy resistance.
Ying-Cheng Deng, Jun-Jie Tian, Li-Jun Zhang et al.· Biochimica et Biophysica Act...· 0 citations
Elevated MXRA5 expression exhibited a positive correlation with advanced lymph node metastasis and impaired clinical prognosis, and its potential as a valuable prognostic biomarker and therapeutic target for managing metastatic disease is revealed.
Jian Wang, Jie Tang, Yaoxin Wang· Korean Journal of Physiology...· 0 citations
ISG20L2 is aberrantly upregulated and associated with malignant biological features and immune-related characteristics in gastric cancer, supporting its potential role as a pro-oncogenic regulator and a candidate molecular indicator requiring further clinical validation.
Song Liang, Chuan-Jun Wang, Yong-Kang Liang et al.· Frontiers in Oncology· 0 citations
Colorectal cancer (CRC) is the second leading cause of cancer-related death. The tumor immune microenvironment plays a critical role in tumor progression and immune evasion. B7-H3 (CD276), a member of the B7 family of immune checkpoint molecules, is frequently overexpressed in a variety of malignancies, including CRC....
Nouran Alwisi, M. Hamid, Dahab Ghith et al.· Cancer Treatment and Researc...· 0 citations
This study identifies ZUP1 as a potential oncogenic factor and a robust independent prognostic biomarker in breast cancer and suggests that ZUP1 is a novel multifaceted biomarker with significant implications for personalized treatment strategies in breast cancer.