Open access
Preserved mitochondrial respiration in presence of oxidative stress and reduced mitochondrial mass after 10‐day bed rest in older adults
Evgeniia S. Motanova
L. Zuccarelli
E. Lysenko
Stefano Amoretti
M. Pirazzini
O. Rossetto
L. Brocca
R. Bottinelli
M. Pellegrino
Giovanni Baldassarre
Clarissa Gissi
Giovanna Lippe
Mladen Gasparini
B. Šimunič
R. Pišot
Bruno Grassi
Marco V. Narici
Medicine
TL;DR
This work aimed to characterise how physical inactivity impacts mitochondrial function, morphology and gene expression in the skeletal muscle of older adults.
Abstract
Ageing affects mitochondrial integrity in skeletal muscle, and physical inactivity may further exacerbate these changes. Although mitochondrial alterations are documented in ageing and disuse independently, how disuse impacts the mitochondrial phenotype in older populations remains unclear. This work aimed to characterise how physical inactivity impacts mitochondrial function, morphology and gene expression in the skeletal muscle of older adults.