Aug 2026· Clinical and Translational Oncology· 0 citations· 95 references
Medicine
TL;DR
Melatonin (MLT), an endogenous indoleamine involved in circadian regulation, has emerged as a potential anticancer molecule due to its pleiotropic effects on tumor biology, and emerging evidence suggests that MLT may enhance the sensitivity of LC cells to conventional therapies through modulation of cellular stress responses and death pathways.
The potential of understanding oxidative stress mechanisms to develop therapeutic strategies that target redox balance and homeostasis, aiming to overcome resistance and improve survival outcomes for glioblastoma patients is discussed.
Salma Lamrabet, Asmae Squalli Houssaini, Sanae Bennis et al.· International Journal of Mol...· 0 citations
Oxidative stress good or evil? Oxidative stress occurs when the balance between reactive oxygen species (ROS) and antioxidant defenses shifts toward an excess of ROS; while essential in physiological processes, it plays a context-dependent role in cancer, contributing to both the promotion and inhibition of tumorigenes...
María Escribano-Cebrián, M. Bataller, M. Biasini et al.· Redox Biology· 0 citations
Molecular hydrogen (H
2
) is a chemically inert, non-toxic, highly diffusible gas that has recently attracted considerable interest as a novel bioactive mediator with growing therapeutic relevance in oncology. Emerging evidence suggests that H
2
modulates multiple pathways involved in cancer initiation and progre...
Anirban Maity, Ajay Mallick, Debbie C. Crans et al.· Frontiers in Chemical Biolog...· 0 citations
A dynamic ROS modulation framework is proposed that advocates for precise, personalized pro-oxidant or antioxidant interventions based on each patient's tumor subtype, real-time redox state, and TIME characteristics, offering a robust translational path for next-generation precision oncology in OC.
Yixin Hou, Yue Jiang, Hui Li et al.· Critical reviews in oncology...· 0 citations
Malignant progression and limited therapeutic response in gastric cancer (GC) cannot be explained solely by increased proliferation or oncogenic alterations. Instead, they reflect how tumor cells regulate their death threshold under sustained damage, metabolic stress and immune pressure. Evidence indicates that GC cell...
Meng-Ru Liu, Zhu-Jun Wu, Qiao Chen et al.· International Journal of Mol...· 0 citations
The c-Myc protein is a key regulator of cell growth, proliferation, and differentiation. Its overexpression or dysregulation is linked to several cancers, including non-small cell lung cancer (NSCLC) and colorectal cancer (CRC). Here, we described ECD, a novel small molecule targeting c-Myc, which disrupts the c-Myc/MA...
Nicharat Sriratanasak· 0 citations
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