Programmable RNA-Guided DNA Recombination: Mechanisms, Engineering, and Applications
The emergence of seekRNA- and bridgeRNA-guided recombination has introduced a distinct paradigm in genome engineering by coupling programmable RNA-directed DNA recognition with recombinase-mediated insertion, excision, inversion, and genomic rearrangement without canonical double-strand breaks. Since their discovery in...
A. A. Ali Agha, Dima Hattab, Athirah Bakhtiar et al.
· Biomedicines · 0 citations