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1,561 papers
The experimental developments that preceded the discovery of induced pluripotency are discussed, major advances achieved over the following two decades are summarized, and the directions in which the field is likely to develop further are considered.
A modular, doxycycline-inducible vector system that integrates gene overexpression, shRNA-mediated knockdown, and CRISPR/Cas9-mediated regulation within a single, lentivirus-compatible system that expands the experimental repertoire for dynamic, multigene interrogation in complex systems.
Two novel monoclonal HLA genes homo/heterozygous knockout hESC lines are presented, along with their multi-omics landscapes, pluripotency and immunogenicity, which exhibit crucial application potential and reference value in the development of hypoimmunogenic hESCs for their universal clinical use.
The prevalence and resistance mechanisms of S. aureus in clinical, food, and environmental contexts are investigated, promising alternative therapies are explored, and the urgent need for global antimicrobial stewardship (AMS) and sustainable intervention strategies are emphasized.
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The context-dependent roles of iron, copper, zinc, aluminum, and manganese in the pathogenesis of AD are reviewed, with a particular focus on their bidirectional interactions with classic AD pathology.
A protocol for delivering CRISPR-Cas9 or prime editors into PDAC cell lines using retrovirus-derived engineered virus-like particles (eVLPs) and adapts readily to other genomic sites.
The rapidly global deployment of COVID-19 mRNA-LNP vaccines established the clinical feasibility of combining RNA medicine with LNP delivery systems, transforming a long-standing experimental concept into a scalable therapeutic modality, previously considered impossible. Currently, the value of mRNA-LNPs has been expan...
This review focuses primarily on the current state of CRISPR-based epigenome editing systems, including acetyltransferases, demethylases, DNA methyltransferases, and deacetylases, and their applications in crop improvement research and critically evaluates their mechanisms in rewriting epigenetic regulatory information...
Genetically modified Plasmodium falciparum parasites expressing transgenes such as fluorescent markers are crucial tools for malaria research. However, current reporter lines often rely on integrated transgene constructs that disrupt the coding sequence of a native gene, potentially affecting progression in the life cy...
Biotechnology has evolved from ancient fermentation practices and the domestication of plants and animals into a multidisciplinary field that integrates molecular biology, genetics, engineering, and computational sciences.This review presents a comprehensive overview of the historical evolution of biotechnology, highli...
Clade V-MLOs are associated with powdery mildew susceptibility in several plants. In grapevine, four MLO genes (MLO3, MLO4, MLO13, and MLO17) belong to clade V and have been studied to determine their contribution to susceptibility to Erysiphe necator (Grape Powdery Mildew—GPM). Using somatic embryogenesis to generate...
General Science
A Blog post by NVIDIA on Hugging Face
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
General Science
General Science
GPT-Lab
· gpt-lab.eu
Oct 8, 2026
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
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