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A. A. Ali Agha

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#gene editing Review Open access Sep 2026

Programmable RNA-Guided DNA Recombination: Mechanisms, Engineering, and Applications

The emergence of seekRNA- and bridgeRNA-guided recombination has introduced a distinct paradigm in genome engineering by coupling programmable RNA-directed DNA recognition with recombinase-mediated insertion, excision, inversion, and genomic rearrangement without canonical double-strand breaks. Since their discovery in...

A. A. Ali Agha, Dima Hattab, Athirah Bakhtiar et al. · Biomedicines · 0 citations