A. Akhmanova

Systematic proteomics identifies a conserved mechanism for polar targeting of plant cortical proteins

Multicellular development is tightly coupled to the polarization of individual cells, which partitions polar proteins along the cell cortex and can control asymmetric cell division, anisotropic growth, local differentiation or physiology. Mechanisms driving cell polarization have been described in fungi and animals, bu...

Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease.

Dissection of centrosomal γ-TuRC activation pathways controlling microtubule density in interphase cells

Animal microtubule-organizing centers, including the centrosome and the Golgi apparatus, regulate microtubule nucleation and anchoring through the γ-tubulin ring complex (γ-TuRC) and CAMSAP-mediated minus-end stabilization. However, functional redundancy between these pathways has impeded dissection of their contributi...

Microtubule Engagement by the WD40-Containing Tail of Kinesin-4 KIF21B

These findings provide a structural framework for tail-mediated microtubule attachment by a neuronal kinesin-4 and suggest how its distinctive WD40 domain may contribute to microtubule regulation and organization of microtubule arrays.

establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling

KIF13B is a novel regulator of ciliary TZ configuration, membrane composition and Shh signalling and it is shown that KIF13B regulates TZ membrane composition and ciliary SMO accumulation.