Oct 2026
Multi-omic and Survival Analysis of Acute Chest Syndrome Burden in Sickle Cell Disease
A. Kulshrestha, M. Garrett, S. Nouraie et al.
· medRxiv · 0 citations
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Human genetics implicates a BACH2-NRF2 axis in fetal haemoglobin activation.
Human genetic studies have identified key regulators of fetal haemoglobin (HbF) expression, including BCL11A, resulting in therapeutic advances1-8. Yet the mechanisms by which HbF expression is activated remain incompletely understood9. Here we conduct a large multi-ancestry genome-wide association study of HbF levels...
Chun-Jie Guo, U. Arora, Xiao-Heng Cheng et al.
· Nature · 0 citations
Open access
Aug 2026
Alcohol use disorder and childhood adversity in the association between polygenic risk and suicidality.
OBJECTIVE Suicidal ideation (SI) and suicide attempt (SA) are both influenced by genetic, behavioral, and environmental factors. Alcohol use disorder (AUD) and adverse childhood experiences (ACEs) may mediate or moderate the effects of genetic liability for suicidality. METHODS Using data from 10,275 participants (43...
V. Wu, X. Qin, A. Ashley-Koch et al.
· Journal of Affective Disorde... · 0 citations
Open access
Aug 2026
Age norms for DunedinPACE: An epigenetic pace of aging biomarker
Age norms for DunedinPACE, an epigenetic Pace of Aging measure derived from DNA methylation, are developed to help integrate biomarkers of aging, such as DunedinPACE, into precision public health and medicine.
K. Bourassa, C. Ryan, K. Sugden et al.
· medRxiv · 0 citations