Molecular therapies for cardiac arrhythmias
The ability of TBX3 to reduce intercellular coupling to overcome current-to-load mismatch and the ability to reduce I K1 density to enable diastolic depolarization, are promising TBX3 characteristics that may facilitate biological pacemaker formation strategies.
M. Bakker, G. J. Boink, Bas J. Boukens et al.
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