The ability of TBX3 to reduce intercellular coupling to overcome current-to-load mismatch and the ability to reduce I K1 density to enable diastolic depolarization, are promising TBX3 characteristics that may facilitate biological pacemaker formation strategies.
Background Loss- and gain-of-function variants in SCN5A, encoding the cardiac sodium channel Nav1.5, are major causes of inherited cardiac channelopathies. Their pathophysiology has almost exclusively been attributed to altered cardiomyocyte excitability and cardiac conduction. However, growing evidence indicates that...
A. Jean, H. Rabeony, C. Magaud et al.· bioRxiv· 0 citations
Cardiac autonomic neurons regulate contractility. Autonomic nervous system dysregulation can cause sympathetic overdrive, leading to heart failure, and fatal arrhythmias. Here, we introduce innervated engineered human myocardium (iEHM), a model of neuro-cardiac junctions, constructed by fusing sympathetic neuronal orga...
L. V. Schneider, Michael Gani Setya, Guobin Bao et al.· Nature Communications· 0 citations
Hypothyroidism is associated with cardiovascular complications, including supraventricular arrhythmias. Thus, this study investigated functional and morphological alterations in the atrial of hypothyroid rats and evaluated the effects of acute ranolazine treatment on arrhythmia susceptibility. Hypothyroidism was induce...
Emanuel Barbosa dos Santos, Jonathan Ezequiel de Souza Bazilio, J. L. Teixeira-Fonseca et al.· Biochemical Pharmacology· 0 citations
Abstract Increased late sodium current (INaL) is a central mechanism underlying both inherited and acquired cardiac arrhythmias. Although Nav1.5 is the dominant cardiac sodium channel, multiple tetrodotoxin-sensitive (TTX-S) Nav isoforms are also expressed in cardiomyocytes, particularly within transverse tubules, wher...
Hugo Millet, M. Choteau-Bodor, T. Stervinou et al.· Europace· 0 citations
Abstract The sinoatrial node (SAN) is the primary pacemaker of the heart, initiating each regular heartbeat through the spontaneous activity of specialized pacemaker cells. Its automaticity is governed by a tightly regulated interplay between ionic membrane currents and intracellular calcium cycling and is highly sensi...
Michele Terren, Moritz Linder, E. Ricci et al.· Current Directions in Biomed...· 0 citations
Highlights
Sorbs2 is an adaptor and cytoskeletal protein predominantly expressed in the cardiovascular system-specifically in cardiomyocytes, vascular smooth muscle cells, and endothelial cells. It plays a critical role in maintaining myocardial structural integrity, regulating contractility, and facil...
Artem G. Atoyan, Margarita A. Zholkovskaya, Amina A. Savlokhova et al.· Complex Issues of Cardiovasc...· 0 citations
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