Author

A. Kazarov

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#protein folding Open access Sep 2026

Comparative Analysis of SMN2 Splicing Activity and Protein Production Following In Vitro Treatment with the Generic Risdiplam Drug Vapromin® and the Reference Drug Evrysdi®

In vitro biological activity of the generic drug Vapromin® is comparable to that of Evrysdi® (Roche, Basel, Switzerland) and further research should be conducted to confirm bioequivalence between the two products.

O. Strizhakova, A. Pershin, Yana Bahareva et al. · Biomedicines · 0 citations

Open access Jul 2026

Tissue specificity and age-related dynamics of CAG promoter activity in rAAV-mediated gene therapy

The CAG promoter is poorly suited for transgene expression in the lung and brain cells due to promoter silencing and is suboptimal for expression in the liver cells because of relatively low activity; these findings should be taken into account in the development of gene therapy products.

R. L. Anisimov, N. V. Nikiforova, E. S. Ivanov et al. · Biological Products. Prevent... · 0 citations