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#protein folding Open access Sep 2026

Building coiled coils with polar cores

Coiled coils are formed by α‐helices winding around each other into superhelical bundles. They are characterized by a specific geometry of interaction, called knobs‐into‐holes, in which residues in the core of the structure mesh regularly along a seam that runs the length of the helices. While these residues are predom...

Marcus D. Hartmann, B. H. Alvarez, Mikel Martinez-Goikoetxea et al. · 0 citations

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