Structure-guided antisense oligonucleotides selectively modulate frameshifting of a human gene
This work provides a conceptual and practical framework for targeting recoding-dependent gene products such as PEG10 in disease and suggests broader applicability of structure-directed ASOs to viral and cellular frameshifting elements.
Ondrej Kostov, Myriam Moreno Swanton, Katie R. Waldon et al.
· bioRxiv · 0 citations