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The articles in this issue of Clinical Pharmacology & Therapeutics illustrate clinical pharmacology at points of decision, which span oncology, infectious diseases, neurology, transplantation, pharmacogenomics, regulatory science, and health-system value.
Quantitative dose optimization in early phase clinical trials for investigational new drugs has been expanding across drug modalities and disease indications in response to the limitations of non‐quantitative or algorithmic methods of dose progression. In the context of the FDA's Project Optimus Initiative, which empha...
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