Aug 2026· Clinical pharmacology and therapy· Vol 120, pp. 573-576· 0 citations· 14 references
Medicine
TL;DR
The articles in this issue of Clinical Pharmacology & Therapeutics illustrate clinical pharmacology at points of decision, which span oncology, infectious diseases, neurology, transplantation, pharmacogenomics, regulatory science, and health-system value.
Abstract
Clinical pharmacology encompasses a broad set of quantitative and translational tools: pharmacokinetics, pharmacodynamics, biomarkers, pharmacogenomics, modeling and simulation, and clinical and real-world evidence. Yet, the discipline’s true value lies not in the methods themselves. Its value lies in turning measurements into consequential therapeutic and development decisions such as which dose should be selected, criteria for treatment continuation or cessation, and quantifying uncertainty around use in each subpopulation. The articles in this issue of Clinical Pharmacology & Therapeutics illustrate clinical pharmacology at these points of decision. They span oncology, infectious diseases, neurology, transplantation, pharmacogenomics, regulatory science, and health-system value. The breadth is characteristic of the field
Clozapine remains the most effective treatment for treatment-resistant schizophrenia, yet its use is constrained by concerns about safety and preventable adverse outcomes. Evidence on clozapine safety remains fragmented and methodologically heterogeneous, limiting translation into clinical practice. Pharmacovigilance,...
This review outlines the historical development and conceptual foundations of QSP and summarizes representative clinical applications spanning early, mid, and late development, and considers emerging challenges and opportunities for QSP adoption.
Wei-Rong Wang, Alexander V. Ratushny, Steven C. Chang et al.· Journal of clinical pharmaco...· 0 citations
Background: Heart failure (HF) While traditional treatments are still a major worldwide burden for mortality and morbidity, innovative treatment and diagnosis methods are urgently needed. Conventional therapies, as applied in the conventional medical model, though able to provide symptomatic relief, are often unable to...
Aisha Alyassi, A. Mary, Mugdha Chavan et al.· Journal of Population Therap...· 0 citations
Pediatric pharmacotherapy has evolved to encompass a broad array of clinical, regulatory, research, and drug development activities. Yet nearly everything done today builds on foundational elements of the discipline. Through examples from a career in pediatric pharmacology and therapeutics, this article challenges read...
S. Abdel-Rahman· The Journal of Pediatric Pha...· 0 citations
Precision medicine is an approach to tailoring disease prevention and treatment based on individual patient characteristics, aiming to deliver the right treatment to the right patient at the right time. Precision dosing relies on clinical tools capable of integrating genotypic and phenotypic characteristics to inform i...
Personalized cancer treatment requires stratification of patients based on biomarkers. Despite advances in biomarker-guided therapy, biomarkers are not always available or sufficient to predict treatment responses in individual patients. Functional ex vivo cancer models with the potential to assess therapeutic outcomes...
Eveline C. Smit, Zofia M. Komar, H. Blommestein et al.· Trends in Cancer· 0 citations
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