Vascular cognitive impairment and dementia (VCID) is a common cause of cognitive impairment, yet validated biomarkers, particularly those reflecting vascular function, remain lacking. Oxygen extraction fraction (OEF), which reflects the functional status of cerebral small vessels, is a potential physiological biomarker...
Jie Song, Wen Shi, Julia Suconic et al.· Alzheimer's & Dementia· 0 citations
Chronic inflammation is a common feature of aging and is observed across various age-related neurodegenerative diseases, including Alzheimer's disease (AD). Diffusion magnetic resonance imaging (dMRI) metrics of white matter microstructure are hypothesized to be sensitive to inflammation, though few studies have assess...
Siona Mishra, C. Pettigrew, Chidi Ugonna et al.· Neurobiology of Aging· 0 citations
Among CU individuals, plasma p-tau217 was associated with subsequent MCI/dementia due to AD and showed the most extensive associations with longitudinal AD-related brain atrophy, compared with SPARE-BA or R-indices capturing subcortical, diffuse cortical, or perisylvian atrophy.
Murat Bilgel, Ishaan Shah, Jasmine M. Cooper et al.· medRxiv· 0 citations
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