Open access
Cerebral oxygen extraction fraction as a physiological biomarker in vascular cognitive impairment: A study in older adults enriched for small vessel diseases
Jie Song
Wen Shi
Julia Suconic
Kaisha Hazel
George Pottanat
Ebony Jones
Tyler Deane
Archana Sharma
Cui-Mei Xu
Kumiko Oishi
Yi-Fan Gou
Zhi-Yi Hu
Xin Li
Paul B. Rosenberg
Rita R. Kalyani
A. Moghekar
Sevil Yasar
Doris Lin
Marilyn Albert
Hanzhang Lu
Deng-Rong Jiang
Medicine
Abstract
Vascular cognitive impairment and dementia (VCID) is a common cause of cognitive impairment, yet validated biomarkers, particularly those reflecting vascular function, remain lacking. Oxygen extraction fraction (OEF), which reflects the functional status of cerebral small vessels, is a potential physiological biomarker for VCID. We tested this hypothesis in older adults enriched for small vessel diseases, controlling for Alzheimer's disease (AD) co‐pathology.