It is demonstrated that AIC excitatory neurons, specifically layer 5 pyramidal neurons projecting to the basolateral amygdala, are essential for higher-order threat learning/memory and a novel circuit mechanism for bidirectional regulation of higher-order threat learning/memory is identified.
Ho Namkung, Bandhan Mukherjee, Josephine de Chabot et al.· bioRxiv· 0 citations
Human induced pluripotent stem cells (hiPSCs) provide a translational platform to interrogate the impact of genetic risk factors for various disorders on human biology. It has been a common practice to engineer premature stop codons to model predicted loss-of-function mutations using isogenic hiPSCs, yet effects of mut...
Yan Hong, Ting Zhao, Qian Yang et al.· bioRxiv· 0 citations
Metabolic alterations in early-stage psychosis may provide insights into disease pathophysiology and potential biomarkers. We performed targeted metabolomic and lipidomic profiling of plasma samples from 31 patients with early-stage psychosis (onset within 24 months) and 22 healthy controls using a liquid chromatograph...
S. Kawaguchi, Kazuhiro Sonomura, K. Ishizuka et al.· Neurosciences research· 0 citations
A significantly elevated genome-wide rare CNV burden in EAS cases compared with controls is observed, underscoring the importance of increasing population diversity to fully capture the genetic underpinnings of schizophrenia.
Yu Chen, Qi-Di Feng, Max Lam et al.· Nature Genetics· 0 citations
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