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Author

A. Straight

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Open access Sep 2026

Meiotic kinetochore reconstitution identifies chromosome segregation factors

Kinetochores are complex protein assemblies at centromeres that direct and regulate chromosome segregation1. During gamete formation by meiosis, kinetochore specialisations drive two sequential and distinct segregation events to partition half the genome to the offspring2,3. Age-dependent segregation errors in human oo...

G. Pieper, Niamh O'Loughlin, M. Aboelenain et al. · 0 citations
Review Aug 2026

Structure and function of the outer kinetochore

This Review focuses on how the handful of KMN complexes present at each microtubule-binding site achieves this complex regulation with high accuracy.

Andrea Musacchio, Pim J. Huis In 't Veld, Rae R. Brown et al. · 1 citation

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