Author

A. van Mil

2 papers indexed here

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Open access Sep 2026

A study on extracellular and cellular composition to advance towards the rational design of contractile human myocardium

The recapitulation of the physiological cellular composition, 3D structure and mechanics of the human myocardium is key to improving the biofabrication of cardiac tissues. To advance the development of engineered heart patches, with significant potential for human cardiac repair, we assessed the impact of their cellula...

O. Iglesias-García, A. Ullate-Agote, Jian Qin et al. · Materials Today Bio · 0 citations

Aug 2026

Vitronectin-driven amyloid deposition disrupts mitochondrial homeostasis via integrin-mediated pathway in a humanized mouse model of transthyretin cardiac amyloidosis.

Modulation of integrin signalling represents a potential complementary therapeutic strategy in ATTR-CM beyond TTR suppression and actively drives cardiac amyloid deposition, and disruption of integrin αvβ3/FAK/Akt signalling links amyloid-ECM interactions to mitochondrial dysfunction.

Zeping Qiu, Yingze Fan, J. Qin et al. · European Heart Journal · 1 citation