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Vitronectin-driven amyloid deposition disrupts mitochondrial homeostasis via integrin-mediated pathway in a humanized mouse model of transthyretin cardiac amyloidosis.

Zeping Qiu Yingze Fan J. Qin Haikun Qi Qinfang Miao Shu-Dong Zheng Zhiyan Wang Zhihong Sun Yu-Tong Wu Wenbo Yang Yanjia Chen Sha Hua M. Oerlemans A. van Mil Wei Jin
Aug 2026 · European Heart Journal · 1 citation
Medicine

TL;DR

Modulation of integrin signalling represents a potential complementary therapeutic strategy in ATTR-CM beyond TTR suppression and actively drives cardiac amyloid deposition, and disruption of integrin αvβ3/FAK/Akt signalling links amyloid-ECM interactions to mitochondrial dysfunction.

DOI PubMed Semantic Scholar
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