Alzheimer’s disease (AD), involves progressive cognitive impairment primarily associated with cholinergic dysfunction. Dual inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) continue to represent a validated and clinically relevant therapeutic approach for alleviating cholinergic deficits in...
Y. Khan, Hina Sarfraz, Azmatullah Khan et al.· Journal of Computational Bio...· 0 citations
A series of novel bromophenyl-substituted imidazolone derivatives were synthesized from (Z)-4-(2-bromobenzylidene)-2-phenyloxazol-5(4H)-one through reactions with various nitrogen nucleophiles. The antiproliferative activities of the synthesized candidates were evaluated against HepG-2 (liver), MCF-7 (breast), and HCT-...
Mohamed H. Hekal, Mohamed Abdel-Megid, Mostafa E. Salem et al.· RSC Advances· 0 citations
Polyhydroxyalkanoates (PHA) are biodegradable alternatives to conventional plastics, as they can decompose without generating harmful residues, thereby addressing global plastic pollution. In this work, a molecular‐level understanding of solvent‐polymer interactions is achieved using Density Functional Theory (DFT). Th...
A. John, Sneha Anna Sunny, A. Y. Alzahrani et al.· Macromolecular Theory and Si...· 0 citations
Two polyurethane (PU) matrices were synthesized using poly(ε‐caprolactone) diol and 4,4′‐diisocyanato dicyclohexylmethane using two different synthetic approaches. NMR and FTIR spectroscopy analysis ensured the chemical structure and the formation of the matrices. Thereafter, composite materials were prepared by in...
Ahmed Ramdani, T. Harit, Zoubida Aissaoui et al.· Journal of Applied Polymer S...· 0 citations
The therapeutic relevance of N. jatamansi-derived compounds through in-silico evaluation as antiviral agents targeting HIV-1 reverse transcriptase is supported and warrant further in-vitro and in-vivo studies to explore their role as novel antiretroviral agents.
Mohammad Asif, Mazen M. Almehmadi, A. Alzahrani et al.· 3 Biotech· 0 citations
The results suggest that the 2,4-dichlorophenyl–1,2,3-triazole scaffold represents a promising starting point for further optimization, with antimicrobial activity governed by a balance between electronic properties and physicochemical factors influencing membrane permeability.
Mohammed Sallam, A. Hassan, A. Y. Alzahrani et al.· Scientific Reports· 0 citations
These findings highlight pyrazole-based scaffolds as promising antimicrobial candidates with favorable biological profiles, providing a strong basis for further structural optimization.
E. El-Helw, Selwan Hamed, A. El-ziaty et al.· Scientific Reports· 1 citation
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