A. Yiğin

Effect of the balance between flaxseed and animal fat on FADS2 gene expression in the liver of Japanese quail (Coturnix japonica)

This study investigated the effects of dietary lipid composition on hepatic FADS2 gene expression in Japanese quail (Coturnix japonica), focusing on graded combinations of animal fat and flaxseed inclusion. A total of 80 quail were randomly allocated into four dietary groups (n = 20 per group), in which animal fat leve...

Antibacterial, Anti-Inflammatory, and Wound-Healing Effects of Micromeria fruticosa Essential Oil-Loaded Nanoemulsion in MRSA-Infected Diabetic Wounds: In Vitro and In Vivo Evaluation

Background/Objectives: Diabetic foot ulcers infected with methicillin-resistant Staphylococcus aureus (MRSA) heal poorly and respond inadequately to conventional antibiotic therapy. This study developed a Micromeria fruticosa essential oil-loaded nanoemulsion (Mf-NE) as a topical treatment for such wounds. Methods: The...

Synthesis and Characterization of Silibinin-Loaded ZIF-8 Nanocomposites and Their Antibacterial Activity Against Escherichia coli: Insights into acrB, recA, and htpX Gene Expression

Background/Objectives: In this study, ZIF-8 and silibinin-loaded ZIF-8 nanostructures containing different concentrations of silibinin were successfully synthesized using a one-pot method and characterized by FT-IR, SEM, and EDX analyses. Methods: The antibacterial activities of the synthesized nanostructures were subs...

Sustainable Chitosan–PF127 Hydrogel Incorporating Waste Lemon Peel Hydrochar and Pistachio Resin for Antibacterial Activity and MRSA-Infected Wound Healing

It is demonstrated that the combination of waste-derived hydrochar and natural pistachio resin within a CS–PF127 matrix provides a sustainable and effective strategy for the treatment of MRSA-infected wounds, highlighting its potential as a next-generation antibacterial wound dressing.

Silybin-Loaded Chitosan–Gelatin Hydrogels as a Novel Strategy for MRSA-Infected Diabetic Foot Treatment: In Vitro, In Vivo, and In Silico Evidence

In vivo evaluation in an MRSA-infected diabetic foot wound model demonstrated accelerated wound closure and superior healing outcomes for both SB1 and SB2 compared with fusidic acid (Fucidin®) by day 12, suggesting that silybin-loaded CS–Gel hydrogels represent a promising therapeutic platform for the management of MRS...

Antimicrobial, antibiofilm, and virulence gene modulatory effects of supercritical CO₂ extracts of Thymbra spicata against clinical MRSA isolates.