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Review Open access Sep 2026

CSF Tau and Amyloid Biomarkers in Cognitive Impairment Across the ALS–FTD Spectrum: A Systematic Narrative Review and Evidence Map

Cognitive impairment is an important non‐motor manifestation of amyotrophic lateral sclerosis (ALS), particularly across the ALS–frontotemporal dementia (ALS–FTD) spectrum. Cerebrospinal fluid (CSF) tau and amyloid biomarkers may reflect nonspecific neurodegenerative injury, concomitant Alzheimer disease (AD) pathology...

Aasim Ali, Muhammad Arif, Usama Ashraf et al. · 0 citations
Review Open access Sep 2026

Prognostic value of baseline plasma p-tau217 for incident cognitive impairment in cognitively unimpaired cohorts: A systematic review and meta-analysis

Plasma phosphorylated tau 217 (p-tau217) is an accessible biomarker of Alzheimer's disease pathology, but its longitudinal association with incident cognitive impairment in cognitively unimpaired adults remains uncertain. To quantify the prognostic association between baseline plasma p-tau217 and subsequent...

Aasim Ali, Sara Jamil, Aswad Mustafa et al. · 0 citations

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