Review
Open access
CSF Tau and Amyloid Biomarkers in Cognitive Impairment Across the ALS–FTD Spectrum: A Systematic Narrative Review and Evidence Map
Aasim Ali
Muhammad Arif
Usama Ashraf
Saad Elahi
Aswad Mustafa
Mahad Bin Yasir
Waqar Sarfraz
Asad Ullah Ansari
Hafiz Muhammad Yousaf Masood
Muhammad Asad Shabbir
Armaghana Abdullah
M. Sharma
Medicine
Abstract
Cognitive impairment is an important non‐motor manifestation of amyotrophic lateral sclerosis (ALS), particularly across the ALS–frontotemporal dementia (ALS–FTD) spectrum. Cerebrospinal fluid (CSF) tau and amyloid biomarkers may reflect nonspecific neurodegenerative injury, concomitant Alzheimer disease (AD) pathology, or distinct cognitive phenotypes. However, available evidence remains limited, fragmented, and methodologically heterogeneous.