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Post mortem MRI of cholinergic white matter pathways across neurodegenerative diseases

F. López-González M. Němý C. Jerele Andrés Jiménez-Pérez M. J. López-Martínez L. Jonkman Alberto Rábano P. Sánchez-Juan M. Grothe Daniel Ferreira
Sep 2026 · Alzheimer's & Dementia · Vol 22 · 0 citations · 51 references
Medicine

TL;DR

Cholinergic white matter pathway degeneration is central in Alzheimer's disease and Lewy body disease and can be assessed in vivo using magnetic resonance imaging proxies, but neuropathological validation is limited.

Abstract

Cholinergic white matter pathway (CWMP) degeneration is central in Alzheimer's disease (AD) and Lewy body disease (LBD). CWMP degeneration can be assessed in vivo using magnetic resonance imaging (MRI) proxies, but neuropathological validation is limited.

DOI PubMed Semantic Scholar
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