Cholinergic white matter pathway degeneration is central in Alzheimer's disease and Lewy body disease and can be assessed in vivo using magnetic resonance imaging proxies, but neuropathological validation is limited.
F. López-González, M. Němý, C. Jerele et al.· Alzheimer's & Dementia· 0 citations
Hypometabolism is a sensitive and early marker of AD-related neurodegeneration, preceding MRI-detectable GM atrophy and more closely reflecting underlying tau pathology across disease stages.
Orfeas Vourkas, Linda Zhang, Andrés Jiménez-Pérez et al.· European Journal of Nuclear...· 0 citations
Specific AD-SNPs enriched in immune-brain axis pathways rather than Aβ related processes, were associated with reduced volumes of CA1 and subiculum prior to dementia onset, which supports that AD-PRS may capture genetic susceptibility to concomitant neurodegenerative diseases frequently misdiagnosed as AD.
C. Olivé, I. de Rojas, Linda Zhang et al.· Frontiers in Aging Neuroscie...· 0 citations
It is concluded that rare coding CNVs in a proportion of AD-associated genes and 22q11.21 duplication as a strong AD-risk-decreasing factor increase AD risk and Conversely, 22q11.21 duplication as a strong AD-risk-decreasing factor is identified.
O. Quenez, Catherine Schramm, K. Cassinari et al.· American Journal of Human Ge...· 1 citation
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