Author

Abdessamad Elkaoutari

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Open access Sep 2026

The atypical cadherin CELSR2 regulates distinct epithelial–mesenchymal states and oxidative phosphorylation in triple-negative breast cancer

These findings identify CELSR2 as a previously unknown regulator of epithelial-mesenchymal plasticity and reveal that heterogeneous CELSR2 expression shapes spatially and functionally distinct tumor cell populations, thereby contributing to intratumoral heterogeneity in TNBC.

Julia Koren, Nour-Islem Yanis Saidani, Abdessamad Elkaoutari et al. · bioRxiv · 0 citations

Open access Jul 2026

Metalloprotease-driven remodeling of PTK7 and the cell surfaceome promotes metastatic fitness of circulating colorectal tumor cells

A reversible and cell-autonomous remodeling of the circulating tumor cell surfaceome in patients that confers resistance to anoikis and stress induced by entry into the bloodstream is described.

O. Cabaud, A. Aulas, Alexia Lopresti et al. · bioRxiv · 0 citations