Open access

Metalloprotease-driven remodeling of PTK7 and the cell surfaceome promotes metastatic fitness of circulating colorectal tumor cells

O. Cabaud A. Aulas Alexia Lopresti Claire Acquaviva P. Finetti Charlotte Dessaux Laetitia Ganier Quentin DaCosta Claire Germier L. Mescam Abdessamad Elkaoutari S. Audebert Luc Camoin B. de Rauglaudre L. Boudin E. Denicolai Gwenael Lumet A. Cohendet Maelle Picard D. Birnbaum Caroline Gouarné Brice Chanez C. de Chaisemartin B. Lelong Sylvie Marchetto A. Gonçalves Daniel Birnbaum F. Bertucci J. Borg E. Mamessier

Jul 2026 · bioRxiv · 0 citations

Biology

TL;DR

A reversible and cell-autonomous remodeling of the circulating tumor cell surfaceome in patients that confers resistance to anoikis and stress induced by entry into the bloodstream is described.

DOI Semantic Scholar

Read PDF

Similar papers

Open access Sep 2026

Ezrin Functions as a Key Mechanosensitive Effector to Preserve Cell Structure and Promote Survival and Metastasis of Lung Cancer Cells during Circulation

Metastasis remains the leading cause of cancer-related mortality, a process in which circulating tumor cells (CTCs) play a central but incompletely understood role. Although most CTCs are rapidly eliminated during circulation through detachment-induced anoikis and fluid shear stress (SS)-triggered apoptosis, a subset o...

Xiao-Yi Zhang, Mu-Ya Zhou, Kou-Kou Li et al. · International Journal on Bio... · 0 citations

Open access Aug 2026

PIK3CA silencing restores anoikis sensitivity in endothelial cells

The development, differentiation, and homeostasis of adherent cells are regulated by interactions among cells, the extracellular matrix (ECM), and soluble factors. Loss of these contacts induces anoikis, a specific form of apoptosis. Tumor cells acquire resistance to anoikis, enabling them to survive without anchorage,...

Diego Mauro Carneiro Pereira, Ana Paula de Sousa Mesquita, Amanda da Silva Cruz et al. · Molecular Biology Reports · 0 citations

Open access Oct 2026

Histone H4K5 lactylation-driven feedback loop modulates glycerol-linked immunosuppressive activity of tumor-associated T regulatory cells

Tumor metastasis is the leading cause of death for more than 90% of cancer patients, with colorectal cancer (CRC) mainly spreading to the liver. The colon and liver possess distinct nutritional microenvironments, yet how these differences shape the tumor immune landscape remains unclear. Using single-cell analysis of a...

Wang-Zheng Wang, Bai-Da Kong, Chang-Yuan Huang et al. · Signal Transduction and Targ... · 0 citations

Open access Aug 2026

TRDMT1 slows lung cancer growth by stabilizing TFRC mRNA and triggering ferroptosis cell death

A novel TRDMT1-TFRC regulatory axis that suppresses LUAD progression through the modulation of ferroptosis is unveiled, highlighting this pathway as a promising therapeutic target for future interventions.

Ying Zhu, Zu-Li Jiang, You-Ming Chen et al. · Journal of Biological Chemis... · 0 citations

Open access Sep 2026

O-GlcNAcylated TCF4 Drives Ferroptosis Resistance and Tumor-Associated Macrophage Infiltration to Promote Colorectal Cancer Liver Metastasis

Background: Colorectal cancer liver metastasis (CRLM) remains a major cause of mortality in colorectal cancer (CRC), while the upstream molecular mechanisms linking tumor cell adaptation and immune microenvironment remodeling remain poorly understood. Methods: By integrating single-cell RNA sequencing, multi-omics anal...

Han Yang, Jin-Hao Yu, Dong Hou et al. · Cancers · 0 citations

Open access Aug 2026

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer. F7 was highly expressed in tumor tissues and closely associ...

Lei Gao, Qin-Ying Han, Yunpeng Wang et al. · Advancement of science · 0 citations