The atypical cadherin CELSR2 regulates distinct epithelial–mesenchymal states and oxidative phosphorylation in triple-negative breast cancer
These findings identify CELSR2 as a previously unknown regulator of epithelial-mesenchymal plasticity and reveal that heterogeneous CELSR2 expression shapes spatially and functionally distinct tumor cell populations, thereby contributing to intratumoral heterogeneity in TNBC.