Adnan Amin

Atorvastatin-loaded HPMC/Eudragit composite hydrogel film dressings: physicomechanical properties, sustained release, and wound-repair performance.

Hydroxypropyl methylcellulose (HPMC)/Eudragit L100 composite hydrogel film dressings were developed for the localized and sustained delivery of atorvastatin to excisional wounds. Solvent-cast formulations containing different HPMC/Eudragit ratios were screened for swelling, mass loss, and tensile strength, and the opti...

Pathway-specific mechanisms, therapeutic applications, and toxicodynamic profile of acriflavine in cancer: a comprehensive review.

Calcium licenses lipid droplets for ferroptosis: A PKCβ-ACSL4-ALOX15 phosphorylation relay.

Ferroptosis is executed by iron-dependent phospholipid peroxidation, yet the upstream signals that determine when oxidizable lipid pools become lethal remain incompletely resolved. Recent work identifies a calcium-dependent protein kinase C beta (PKCβ) pathway that phosphorylates acyl-CoA synthetase long-chain family m...

Causal Validation of Mobile RNA and Extracellular Vesicle Signals in Plants: Experimental Frameworks for Sequential Stress Acclimation.

Long-distance molecular transport contributes to coordination between locally stressed tissues and distal organs, but assigning causal systemic-signaling functions to mobile RNAs and extracellular vesicle (EV)-associated molecules remains experimentally challenging. This review critically evaluates the evidence require...

Single-cell and spatial transcriptomics inform mechanistic physiology in non-model animals

This review provides a physiology-centered blueprint for applying single-cell RNA sequencing, single-nucleus RNA sequencing, and spatial transcriptomics to non-model species and critically evaluates dissociation and preservation bias, genome annotation, seasonal and ecological variation, biological replication, pseudor...

Cross-stress memory in plants: mobile RNAs, extracellular vesicles, and local-to-systemic signal integration

This review proposes that cross-stress memory should be reconsidered as a systemic signaling phenomenon, in which local stress encounters generate transmissible molecular information that reshapes distal tissue responsiveness and influences later reactions to the same or different stresses.

Integrative Assessment of Evidence for Anagenetic Speciation in Ulleungdo Endemic Plants: Plastid, Nuclear, and Morphological Perspectives

This critical mini-review evaluates whether plastid-based hypotheses for the origin and diversification of Ulleungdo endemics are supported by independent molecular and phenotypic evidence and indicates that robust taxonomic, evolutionary, and conservation inference requires population-level integration of independentl...

Biotic and abiotic elicitors in plant in vitro culture systems: molecular signalling, metabolic reprogramming, and scalable production of bioactive compounds

By linking molecular signalling with metabolic flux and process engineering, this review identifies the experimental and translational priorities required to convert laboratory-scale elicitation into reliable biofactories for plant bioactive compounds.

Resilient forest remedies: biochemical diversity, health benefits, and conservation of medicinal berries in changing ecosystems.

The need to protect medicinal berry resources while improving their responsible use in food, nutraceutical, and value-added agricultural systems is highlighted by integrating phytochemistry, food functionality, ecological adaptation, and conservation.

Polyphenol-based modulation of the Glo1–Nrf2–RAGE axis in diabetes and neurodegeneration: mechanistic evidence, translational constraints, and critical appraisal

Key polyphenols, such as quercetin, resveratrol, curcumin, epigallocatechin gallate, luteolin, and apigenin, enhance Glo1 expression and activity, promote Nrf2 nuclear translocation via Keap1 modification, and lower RAGE expression and ligand binding, but numerous challenges hinder their clinical translation.

Delivering Degradation: Nanomedicine and Programmable Proximity Platforms for Targeted Protein Degradation

This critical review is an outline of all lipid, polymeric, inorganic, biomimetic, targeted, activatable, and self-assembling delivery systems for TPD, and assess compositional considerations, in vitro and in vivo evidence, challenges for translation, and clinical endpoints required to support delivery-enabled degradat...

CRISPR–cas systems in pharmacology: functional pharmacogenomics, drug screening, resistance, and therapeutic translation

Overall, CRISPR-Cas9 represents a vital platform for future pharmacological innovation, but its broad clinical use may require further validation of safety, efficacy, durability, and accessibility.