Lipid nanoparticle induced model endosomal membrane disruption
This study uses giant unilamellar vesicles mimicking the endosomal membrane to directly visualize the interaction and membrane disruptions caused by two model LNPs constituted by two different ionizable lipids, establishing a cell-free platform for dissecting individual sub-steps of endosomal escape.
Shreya Pramanik, Aishwarya Vasudevan, Zheng-Hua Liang et al.
· bioRxiv · 0 citations