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Author

Akira Ikari

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6 papers indexed here

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Sep 2026

Enhanced NRF1-mediated proteasome bounce-back and nelfinavir-mediated bortezomib sensitization in gemcitabine/cisplatin-resistant bladder cancer cells.

Findings identify enhanced NRF1-mediated proteasome adaptation as a feature of GC resistance and highlight the need for highly selective DDI2 inhibitors to evaluate DDI2-NRF1 targeting as a strategy to improve PI efficacy in drug-resistant solid cancers.

Atsumi Ota, M. Kawai, Rin Himura et al. · 0 citations
Open access Aug 2026

Cotinine Enhances Androgen Receptor Stability and Promotes Androgen-Dependent Proliferation in Prostate Cancer Cells: An In Vitro Study.

Cigarette smoking is associated with a poor prognosis and reduced efficacy of androgen receptor signaling inhibitors (ARSIs) in prostate cancer patients; however, the underlying molecular mechanisms remain largely undefined. This study investigated the impact of cotinine, the stable primary metabolite of nicotine, on a...

Riri Hayashi, Yudai Kudo, Yuta Yoshino et al. · 0 citations
Sep 2026

Upamostat potentiates bortezomib cytotoxicity and delays proteasome recovery in bortezomib-resistant malignant lymphoma cells through modulation of the DDI2/NRF1 axis.

Findings identify UMS as a candidate DDI2/NRF1-axis modulator that potentiates BTZ-induced cytotoxicity and delays functional proteasome recovery in BTZ-resistant malignant lymphoma cells.

Atsumi Ota, Sota Maruyama, Yudai Kudo et al. · 0 citations
Sep 2026

Identification of a small-molecule inhibitor of nardilysin and its pharmacological effects on transcriptional regulation and inflammatory arthritis.

Nardilysin (NRDC) is a zinc metallopeptidase of the M16 family that participates in diverse biological processes, including ectodomain shedding and antigen processing. NRDC also functions as a transcriptional coregulator, and this coregulatory activity depends on its metallopeptidase catalytic function. However, small-...

Yasutaka Amano, Kiyoto Nishi, Hazuki Sano et al. · 0 citations
#protein folding Open access Sep 2026

Efficient Discovery of Potent AKR1B10 Inhibitors Using Co-folding Model Boltz‑2

Although affinity prediction of protein–ligand binding remains an important challenge, cofolding models are expected to make virtual screening more effective for drug discovery and development. To verify the effectiveness of selecting a tractable number of candidates from a compound library using cofolding models, we s...

Shinya Kawano, Akira Ikari, Satoshi Endo et al. · 0 citations
Open access Jul 2026

Elevation of anticancer drug-induced cytotoxicity by velpatasvir through downregulation of claudin-14 expression in human colorectal cancer cells.

It is suggested that VEL enhances anticancer drug sensitivity in CRC cells through lysosome-dependent downregulation of CLDN14 protein and suppression of Nrf2-dependent oxidative stress responses.

Tomoka Ando, Yuko Mizukami, Shiemi Tosaki et al. · 0 citations

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