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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Aleksander S. Popel

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2 papers indexed here

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Open access Sep 2026

Quantitative Systems Pharmacology Model for Trop-2 Targeting Antibody-Drug Conjugate in Triple-Negative Breast Cancer

TROP2-targeted antibody-drug conjugates (ADCs) have demonstrated promising clinical activity in triple-negative breast cancer (TNBC) as monotherapies; however, therapeutic benefit varies among patients. Combination strategies pairing TROP2-targeted ADCs with immune checkpoint inhibitors are also being investigated. Elu...

Sedat Dogru, A. Suresh, E. Bowman et al. · 0 citations
#protein folding Sep 2026

Quantitative Systems Pharmacology Model Predicts Enhanced Antitumor Efficacy of Combined Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) and Programmed Cell Death Protein 1 (PD-1) Blockade in a Syngeneic Mouse Model of Breast Cancer

Immune-checkpoint inhibitors targeting PD-1 and CTLA-4 have transformed cancer therapy, yet most patients still fail to respond, and the reasons remain incompletely understood. To dissect this heterogeneity and support translational development, we built a preclinical quantitative systems pharmacology model of α-PD-1...

Yu Zhang, Hanwen Wang, Natsuki Furukawa et al. · 0 citations

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