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Author

Alfredo Kirkwood

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Open access Sep 2026

Therapeutic Hypothermia does not prevent dysmaturity of medial ganglionic eminence-derived interneurons in the dorsal hippocampus after neonatal hypoxia-ischemia

Introduction. Neonatal hypoxic-ischemic (HI) brain injury results in a persistent deficit of hippocampal parvalbumin (PV)+ interneurons (INs), despite therapeutic hypothermia (TH). Since INs from the medial ganglionic eminence (MGE) begin expressing PV around time of injury, we hypothesized that HI injury would result...

Harisa Spahic, M. St Pierre, Pritika Parmar et al. · 0 citations
Open access Aug 2026

Visual deprivation in adulthood engages presynaptic plasticity of thalamocortical synapses

It is shown that robust and reversible plasticity can be induced in adult mice by prolonged dark exposure (DE) and light reintroduction (LRx) and that robust plasticity is engaged at thalamocortical synapses in adults by visual deprivation, a non-invasive manipulation with therapeutic potential.

S. Murase, Daniel Severin, Andrew Pranger et al. · 0 citations

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