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Visual deprivation in adulthood engages presynaptic plasticity of thalamocortical synapses

S. Murase Daniel Severin Andrew Pranger Louis E. Dye Cristián Moreno Lukas Mesik Ji Liu Alfredo Kirkwood E. Quinlan

Aug 2026 · bioRxiv · 0 citations · 55 references

Biology

TL;DR

It is shown that robust and reversible plasticity can be induced in adult mice by prolonged dark exposure (DE) and light reintroduction (LRx) and that robust plasticity is engaged at thalamocortical synapses in adults by visual deprivation, a non-invasive manipulation with therapeutic potential.

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