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Author

Ali Najafyar

2 papers indexed here

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Review Open access Sep 2026

Molecular engineering and clinical translation of T cell engaging bispecific antibodies in cancer therapy

This review consolidates recent developments in CD3-engaging bispecific antibody engineering, including format optimization, affinity modulation, selectivity enhancement, and half-life prolongation, as well as clinical applications in hematologic and solid malignancies.

Ali Najafyar, Z. Hajihassan, W. Ibrahim · 0 citations
#protein folding Sep 2026

Design of a high-affinity IL-21 decoy receptor as a novel therapeutic strategy for autoimmune disorders.

Elevated levels of the pro-inflammatory cytokine Interleukin 21 (IL-21) contribute to the progression of autoimmune and inflammatory diseases by binding to its receptor (IL-21R) and activating detrimental signaling pathways in immune cells. Consequently, we developed a recombinant decoy receptor protein designed to com...

Sara Vazifeshenas, Z. Hajihassan, Seyed Shahriar Arab et al. · 0 citations

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