Aug 2026
Integrated single-cell profiling of RNA and DNA interactomes reveals targetable chromatin architectures in cancer
SCIENCE-seq is presented, a multimodal single-cell interactomics platform enabling simultaneous detection of RNA–RNA interactions and chromatin DNA–DNA contacts within individual cells and identifies a glioma-specific trans-chromosomal HOX hub driven by five interacting lncRNAs.
Evgeny Deforzh, Yanhong Zhang, H. Mnatsakanyan et al.
· bioRxiv · 0 citations