Integrated single-cell profiling of RNA and DNA interactomes reveals targetable chromatin architectures in cancer

The human RNA-DNA interactome is cell type-specific and dynamic

The RNA-DNA interactome is established as a new genome regulatory layer that defines and maintains cellular identity and behavior and is shown to be highly dynamic yet reproducibly organized in cell-type specific networks.

Mapping genome-wide RNA-RNA and RNA-DNA interactions in nuclear hubs of male and female Drosophila cells

The sex-specific RNA-RNA interaction map within the nucleus is determined and the target loci of various RNA molecules, including small nuclear RNAs (snRNAs), which are core components of the spliceosome–a ribonucleoprotein complex involved in RNA splicing are pinpointed.

Distinct RNA-RNA spatial interaction sub-networks of transcription factors in hepatic cells

Alternative RNA Splicing in Cancer: Molecular Mechanisms, Functional Consequences, Biomarkers and Therapeutic Opportunities

This review integrates the molecular logic of splice-site selection with the cancer-specific mechanisms that perturb it, summarizes representative isoform switches across the hallmarks of cancer, evaluates emerging technologies and clinical biomarkers, and discusses the opportunities and constraints of translating spli...

The emerging roles of non-coding RNAs in cancer.

This review examines how different types of ncRNAs contribute to cancer initiation, progression, and treatment resistance, and assesses their potential as diagnostic markers, prognostic factors, and therapeutic targets.

PTBP1 controls oncogenic transcript processing and maintenance of acute myeloid leukemia.

Findings demonstrate that PTBP1 supports AML proliferation by fine-tuning the expression and splicing of AML-essential genes, providing a workflow for systematically annotating RNA-associated protein dependencies in cancer.