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PTBP1 controls oncogenic transcript processing and maintenance of acute myeloid leukemia.

Zhendong Cao Kurtis N. McCannell Si-Xiang Yu Krista A. Budinich Won Jun Kim Yu-Qing Jing Michelle Wang Steven Tittley Z. Wen K. Liu Jun-Wei Shi Omar Abdel-Wahab
Aug 2026 · Leukemia · 0 citations · 92 references
Medicine

TL;DR

Findings demonstrate that PTBP1 supports AML proliferation by fine-tuning the expression and splicing of AML-essential genes, providing a workflow for systematically annotating RNA-associated protein dependencies in cancer.

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